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This paper studies the scheduling problem of discrete equipment manufacturing workshops for major equipments in the context of commercial aircraft engine assembly workshops. At present, the manufacturing process of aircraft engines is still based on manual assembly, involving a large number of tooling parts, the workshop has large flow and long assembly period but limited labor. In this paper, the production scheduling process is optimized under the condition of multi-skilled human resources constraints. The mathematical programming model is established by abstracting the problem, and a heuristic algorithm based on multi-priority rules suitable for this problem is selected to solve the problem. Then, using Plant Simulation to establish a simulation model for the actual discrete assembly system, input different scheduling schemes and combine the logistics process for collaborative verification, and analyze the best scheduling results as a guide. The research shows that this method can effectively guide the workshop operation process, adapt to the constantly adjusted workshop layout, improve the resource utilization rate and assembly efficiency, and has a strong reference for practical application.