There is a high incidence of stroke in male children and in children with SCA. Coexistence with α-thal and haplotypes of the beta globin chain cluster did not show any significant association with stroke. The heterogeneity between previously evaluated populations, the non-reproducibility between studies, and the need to identify factors associated with stroke in patients with SCA indicate the necessity of conducting further research to demonstrate the relevance of genetic factors in stroke related to SCD.

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A Doença Falciforme (DF) é uma patologia monogênica autossômica recessiva com alta prevalência no Brasil. Segundo o Ministério da Saúde há 25 a 30 mil casos de DF, com incidência de 3.500 casos/ano, com destaque para a Anemia Falciforme que tem o maior impacto clinico social e epidemiológico. Minas Gerais por meio da Fundação Hemominas é pioneira na