The development of smart cities is based on the use of new technologies. One of these promising technologies is Blockchain. The use of Blockchain gives great opportunities for solving a complex of problems related to: ensuring energy efficiency in buildings, the introduction of sustainable energy technologies for megacities, the formation of eco-friendly settlements, etc. The article analyzes the possibilities of using Blockchain technology in the social sphere of the city. The analysis is carried out on the example of health and pharmaceuticals. The study was carried out in the framework of the institutional approach and the concept of economic opportunities. The objectives of the study were: to identify specific areas of use of Blockchain technology in the pharmaceutical and health care industries; to evaluate the role of this technology in ensuring compliance with medical standards, transparency and safety of drugs at all stages of their development, promotion and use; to determine the possibilities of technology in identifying more effective and high-quality treatment methods, their implementation in practical health care. The article presents the structure of the areas of pharmaceuticals and health care, where the Blockchain is used. The strategies are offered to reduce labour and energy costs for processing medical information, accelerating the creation of new treatment technologies and the creation of medicines, their implementation in practical health care..