The fruit of Lagenaria breviflora R. was obtained and subjected to methanol extraction. The chemical compound in the extract was analyzed using a Gas chromatography coupled with mass spectrophotomter (GC-MS). The screening of the fruit extract revealed important phytochemicals such as Phenols, Alkaloids Carotenoids and Flavonoids. The analysis of the GC-MS revealed that hydrocarbons as the most abundant compound in the extract and a total of 30 compounds were identified. The major components are octadecane (19.25%), hexacosane (10.9%), docosane (9.15%0, 2 methyl-E,E-3,13- octadecadienol (8.33%), heptadecane (8.18%), tricosane (4.36%), tridecane (3.71%), 1,2-Benzenedicarboxylic acid, mono (2-ethylhexyl) ester (3.63%), tetracontane, 3,5,24-trimethyl- (3.38) and 9,12-Octadecadienoic acid (Z,Z)- (2.64%). Some of the compounds obtained have been reported to have potentials for prophylactic and therapeutic treatment of diseases in both man and animals.