The reaction of hydrazones of 2-aminoacetophenone with triphosgene in dichloromethane or benzene in the presence of triethylamine gave quinazolines, pyrazolo[1,5-c]quinazoline and spiro quinazoline dimers. The latter compounds are being reported for the first time. In addition, a 4,4-disubstituted quinazoline derivative is prepared and its x-ray crystal structure is reported.

Novel spiro 1,3-benzoxazine dimers are obtained when hydrazones of 2-hydroxyacetophenone are treated with triphosgene. An X-ray crystal structure, and the NMR and mass spectra of these new compounds, are reported and discussed.

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Quinazoline, Pyrazolo[1,5-c]quinazoline and Spiro Quinazoline Dimers from the Reaction of 2-Aminoacetophenone Hydrazones with Triphosgene. -The reaction of hydrazones (III) with triphosgene (IV) yields quinazoline, pyrazolo[1,5-c]quinazoline and spiro quinazoline derivatives. The X-ray crystal structure of (X) (no yield given) is given. -(ALKHATHLAN*, H. Z.; AL-SAAD, M. A.; AL-HAZIMI, H. M.; AL-FARHAN, K. A.; MOUSA, A. A.; J.

Cyclization of hydrazones derived from 2-acetyl-1-naphthol and 1-acetyl-2-naphthol with triphosgene gave naphtho[1,2-e]-1,3-oxazines, naphtho[2,1-e]-1,3-oxazines or their spiro dimers depending on the molar ratio of triphosgene used for the cyclization.

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