fQRS predicts arrhythmic events in patients with HOCM and should be considered in a model of risk stratification.

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In vivo 31P magnetic resonance spectroscopy(MRS) was used to evaluate the effect of nimodipine on changes of pH and the ratio of PCr/Pi in cats subjected to an incomplete global cerebral ischemia-reperfusion under the pretreated condition of hyperglycemia. DESIGN:Prospective,controlled animal study. SUBJECTS:Animals were subjected to a transient (18 minutes) incomplete global ischemia : the systemic arterial hypotension was induced, and immediately followed by the bilateral carotid artery ligation. METHODS:Twenty cats were divided into 3 groups: for group 1(control), 7 cats were employed for a control group; for group 2(hyperglycemia), 7 cats were a hyperglycemia group with infusion of 50% glucose prior to ischemia; for group 3 (nimodipine), 6 cats were infused with 50% glucose prior to ischemia, and nimodipine after ischemia. The time course of changes in pH and PCr/Pi was monitored before, during and after ischemia. RESULTS AND STATISTICAL ANALYSES:The pH decreased immediately after ischemia in all three groups. After the reperfusion was made, the values of the pH did not return to the baseline for the group 2 and 3, in contrary to the group 1. The ratio of PCr/Pi was dropped to 20% of the baseline value after ischemia in all three groups. The value was recovered progressively during reperfusion period for group 1, whereas for group 2 and group 3 the values were remained depressed. For statistical analyses unpaired t-test and Wilcoxon signed rank test were used. CONCLUSION:The results suggest that the condition of hyperglycemia induced by the infusion of 50% glucose prior to the incomplete global cerebral ischemia-reperfusion, may deteriorate the cerebral ischemia and infusion of nimodipine during ischemia-reperfusion has no beneficial effects to improve the cerebral acidosis and the metabolic recovery.