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In classical liiear regression model for analysis of medical data concerning hepatic extraction of insulii and c-peptide the bdarnental assumption is that the subjects involved an of a similar nature. In reality, if this assumption is violated then the precision of the results is questionable. This paper suggests a robust alternative to overcome this problem. It is observed that the robustification may be a better option to determine an optimal quantity of insulin which rninimizcS the risk of damage associated with diabatic treatments.

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The dynamic clustering (DC) algorithm is a method for discovering clusters in a given population. Unfortunately the classical DC algorithms fail to perform well in the presence of outliers. A robust dynamic clustering (RDC) algorithm is introduced to overcome this problem. Robust estimates of the location vector and the covariance matrix are calculated in the affine invariant case. A simulation study is presented to demonstrate the basic difference between the DC and the RDC algorithms. Three kinds of optimization criteria are used in case of contaminated multivariate normal distributions.