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an online international journal allowing free unlimited access to abstract and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications. Submission of Manuscript:The International Journal of Health Research uses a journal management software to allow authors track the changes to their submission. All manuscripts must be in MS Word and in English and should be submitted online at http://www.ijhr.org. Authors who do not want to submit online or cannot submit online should send their manuscript by e-mail attachment (in single file) to the editorial office below. Submission of a manuscript is an indication that the content has not been published or under consideration for publication elsewhere. Authors may submit the names of expert reviewers or those they do not want to review their papers. Enquiries AbstractPurpose: In the last few years, aspirin has become a life saver against cardiovascular accidents. This investigation was carried out to determine possible bioequivalence between regular aspirin and soluble aspirin tablets marketed in Nigeria. Methods:The in vivo bioavailability profiles of three commercial brands of aspirin tablets and soluble aspirin tablets were assessed in eight healthy subjects. Pharmacokinetic parameters including amounts of aspirin excreted up to 24h (E 24h ), maximum excretion rate (dE/dt) max and time for maximum excretion rate (T max ) were compared for all the brands. Results: There was no significant difference (p > 0.05) in the maximum excretion rates among all the brands but the amount of soluble aspirin excreted up to 24 hours was a significantly different (p< 0.05) from one of the regular brands of aspirin. The soluble brand had significantly lower T max (p < 0.05) than all the three plain brands. There was no significant inter-subject variation among the subjects that participated in the study. Conclusion:Bioinequivalence exists between some regular aspirin and soluble aspirin marketed in Nigeria.

The variable factors of erosion rate, swelling rate, and porosity were used in studying the release patterns of theophylline from our Cissus populnea polymer (CPP) matrices under the different factor combinations given by a simple 2n factorial experimental design. The zero-order slopes and correlation coefficients representing release rate and linearity, respectively, as obtained from both the nonsteady state and steady state were statistically treated. It appears that the nonsteady-state analysis is more suitable for studying the effects of individual factors, while the steady-state analysis appears more suitable for studying interaction effects of the factors. The study also showed that erosion is the main mechanism by which theophylline is released from the matrices, while swelling is responsible for maintaining linearity in the zero-order release curves. A careful examination of the statistical results shows some functional relationships between the factors, which should be considered in designing more detailed factorial experiments to enable the establishment of equation models for predicting the release profile of theophylline from our CPP matrices under any given dissolution condition.

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