Ameliorating effects of vitamin E and coriander (Coriandrum sativum L.) seed extract on lead-induced renal damage in Swiss albino mice were investigated in the present study by gross and histological studies. Intoxication with a particular dose of lead acetate was done for 42 days through the oral route. The intoxicated mice were divided into three groups for treatment purposes. The first, second and third groups of mice were treated orally with the vitamin E, coriander seed extract and both the vitamin E & coriander seed extract, respectively. Treatment was done for 42 days. In the present study, the weight of the left kidney was significantly (p<0.05) reduced in lead-intoxicated mice in comparison to the control group. Lead acetate was found to cause nodular lesions as well as epithelial cast in the kidney. Vitamin E and coriander seed extract were found effective in the treatment of lead intoxicated mice. Kidneys were found normal in the vitamin E and coriander seed extract treated groups. These results of this study suggested that vitamin E and coriander seed extract are being used to protect against lead-induced kidney injuries.