Nasopharyngeal Carcinoma (NPC) is an epithelial carcinoma originating from the nasopharynx mucosa lining. It is the most common head and necks malignant globally, especially in Asia. NPC is mostly located in Fossa of Rosenmüller, an area that is hard to observe. To diagnose NPC, radiologic imaging and endoscopic examination are necessary. White Light Endoscopy (WLE) is a basic standard endoscopy examination that can be used to diagnose NPC. On the other hand, many studies were expecting for another examination, Narrow Band Imaging (NBI), to be more sensitive in diagnosing NPC than WLE. This meta-analysis aimed to compare the diagnostic performance between WLE and NBI in NPC detection. A literature search was performed using medical literature databases such as PubMed, BMC, Research Gate, and Medical Journal. The studies that we used were published in 2011-2021. Review Manager 5.4.1 was utilized to analyze data extraction and the risk of bias. Seventeen studies were expecting used in this meta-analysis. All of those studies had fulfilled inclusion criteria. The WLE's sensitivity was 2-90 % and its specificity was 0-100% (95% CI). Meanwhile, NBI's sensitivity was 60-100% and its specificity was 0-100% (95% CI). NBI was more sensitive in diagnosing NPC than WLE, but both had the same specificity value. Further studies might be useful to validate this examination.
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