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Dileucine ]-oxytocin has been synthesized by the solid phase method and its pharmacological properties compared with those of [4-leucine]-oxytocin, an analog of the hormone which possesses a marked inhibitory effect on the antidiuretic activity of arginine-vasopressin (anti-ADH). [3,4-Dileucine]-oxytocin was found to possess very weak oxytocic and avian vasodepressor activities and negligible pressor activity. The analog had no antidiuretic activity and no demonstrable anti-ADH activity. However, it had marked natriuretic activity.

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