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Liver cirrhosis (LC) should be considered as a severe, progressive disease with systemic manifestations. Early detection and elimination of risk factors for the development of LC complications are essential for improving the quality of life of patients. In order to study the clinical aspects of the initial stages of LC, we examined 207 patients with LC HBV and HDV etiology. The study of the characteristics of the initial manifestations of LC is necessary to identify predictors of the development of severe complications and prevent disability of patients.

The article is devoted to the study of the connection between the replicative activity of HBV DNA and HDV RNA with the formation of CP at all stages of development of chronic hepatitis of viral nature, evidence that a high level of HBV DNA is a pronounced predictor of liver cirrhosis (LC) progression. The purpose of the study is to study the dependence of the severity of liver damage on the replicative activity of the hepatitis B virus and D. Materials and methods. The study included 67 patients with cirrhosis of the liver in the outcome of viral hepatitis B and 140 patients with an outcome of cirrhosis against the background of chronic hepatitis B + D. The clinical stage of LC was determined according to the Child-Puy classification. Results. A direct link has been established between the increase in the viral load of HBV DNA and HDV RNA with the duration of the disease. A tendency was revealed to increase the severity of the disease in patients with LC of viral etiology with an increase in viral load. The biochemical indices of blood showed a tendency to an increase in the level of cytolytic enzymes against the background of high replicative activity of HBV DNA and HDV RNA. The conclusion. Thus, a high level of HBV DNA is a pronounced predictor of the progression of LC at all stages of the pathological proces

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