No abstract

The expeditious progress of machine learning, especially the deep learning techniques, keep propelling the medical imaging community's heed in applying these techniques in improving the accuracy of cancer screening. Among various types of cancers, breast cancer is the most detrimental disease affecting women today. The prognosis of such types of disease becomes a very challenging task for radiologists due the huge number of cases together with careful and thorough examination it demands. The constraints of present CAD open up a need for new and accurate detection procedures. Deep learning approaches have gained a tremendous recognition in the areas of object detection, segmentation, image recognition, and computer vision. Precise and premature detection and classification of lesions is very critical for increasing the survival rates of patients. Recent CNN models are designed to enhance radiologists' understandings to identify even the least possible lesions at the very early stage.

Today breast cancer is the leading type of cancer among women undergoing cancer screening. A slight delay in detecting and diagnosing this disease may result in irreversible convolutions. Histopathological images from the biopsy examination present a large amount of structural information that can signi cantly improve the prognosis for breast cancer. The pathological analysis, which involves the microscopic examination of the histopathological slides, is a challenging task. An automated computer-aided detection (CAD) procedure is inevitable, as it may decrease the pathologist examination time and help detect the disease at an early stage. Lately, deep learning methods using arti cial neural networks are consistently in use to improve the performance of CAD methods. A common practice among recent studies is to use the transfer learning approach of training deep neural network architectures. Transfer Learning is an established learning approach that facilitates a deep neural network to train quickly on a speci c dataset and resolve an interdisciplinary problem. Deep Learning methods employing the transfer learning approach have provided highly competitive results on the datasets consisting of the whole slide images, which are captured generally at high resolutions. However, the performance is not remarkably appreciable on the small and low-resolution image datasets, in particular the datasets that include patch samples. In this direction, the present study proposes a novel domain-speci c learning strategy, Breast Histo-Fusion, which aims to detect breast cancer even from images of low resolution and small size. Further, four state-of-the-art deep CNNs (AlexNet, VGG19, ResNet, and DenseNet) are trained using both learning approaches: Transfer Learning and Histo-Fusion on the IDC dataset. The proposed Histo-Fusion learning approach has improved the discriminating abilities and performance of each deep CNN by providing better results of (AlexNet -95.75%, VGG19-95.96%, ResNet34-96.17%, ResNet50-96.67%, and DenseNet121-97.49%) compared to (AlexNet -90.41, VGG19-90.51%, ResNet34-90.83%, ResNet50-92.27%, and DenseNet121-93.05%) using the transfer learning strategy. As a result, the procedure can help expert pathologists to perform accurate diagnoses and reduce false-positive rates.

The expeditious progress of machine learning, especially the deep learning techniques, keep propelling the medical imaging community's heed in applying these techniques in improving the accuracy of cancer screening. Among various types of cancers, breast cancer is the most detrimental disease affecting women today. The prognosis of such types of disease becomes a very challenging task for radiologists due the huge number of cases together with careful and thorough examination it demands. The constraints of present CAD open up a need for new and accurate detection procedures. Deep learning approaches have gained a tremendous recognition in the areas of object detection, segmentation, image recognition, and computer vision. Precise and premature detection and classification of lesions is very critical for increasing the survival rates of patients. Recent CNN models are designed to enhance radiologists' understandings to identify even the least possible lesions at the very early stage.

No abstract