Compounds having quinolone and pyrimidine skeleton plays an important role in the medicinal chemistry. The objective of the present work was to modify the Biginelli reaction by using heterocylic ketones under microwave condition. We have demonstrated new synthetic route of quinolone fused 1,4-dipyrimidines by the reaction of 6-methyl-4-hyrdoxyquinolin-2(1H)-one (1), substituted aromatic aldehydes (2a-g) with phenyl urea (3). The structure of these newly synthesized compounds was characterized IR, NMR, Mass spectral and elemental analysis.

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Herein, a novel ionic liquid catalyzed synthesis of 3-acetylpyrano[2,3-b]quinolin-2(1H)-ones (3a-e) from substituted 3-formylquinolin-2(1H)-ones (1a-e) and ethyl acetoacetate (2) through Knoevenagel condensation is reported. We have perceived the application of microwave irradiation and ionic liquid for carrying out pollution free and ecofriendly chemical reactions. These reactions proceeded much faster in ionic liquid medium under microwave irradiation. The structures of quinoline derivatives (3a-e) were characterized by standard physico-chemical techniques. The synthesized quinoline derivatives (3a-e) were also evaluated for their in vitro antimicrobial screening on different strains of bacteria and fungi.