Aims: The effects of quercetin and Emilia sonchifolia on the lipid profile in Cadmium chloride induced oxidative stress were investigated in this study Methodology: Twenty-four (24) male albino Wistar rats aged 5-6 weeks old and weighing 100-170g were divided into four groups of six rats each; consisting of normal control group, CdCl2 untreated group, QE treated group and ES treated group. In the initial phase of the experiment called the induction phase, Group 1 being the NC group received distilled water orally and the rest of the experimental groups were orally administered CdCl2 at a dose level of 5mg/kg b.w/day for 21 days.  In the next phase of the experiment called the treatment phase Group 1 and 2 being the NC and CdCl2 untreated groups respectively, were orally administered 0.07ml of 2% tween80. Group 3 being QE treated group was administered quercetin at a dose level of 20mg/kg b.w/day + 0.07ml of 2% tween80. Group 4 being ES treated group was administered Emilia sonchifolia at a dose level of 575.8mg/kg b.w/day + 0.07ml of 2% tween80 for 28 days. After the treatment period of 28 days, the animals were fasted overnight, anesthetized and sacrificed. Whole blood was collected for biochemical assay. Results: Results showed that cadmium decreased body weight and significantly  increased serum levels of TG, TC, LDL-C and VLDL-C across the treatment  groups. Conclusion: Marked positive response were observed following treatment with quercetin and Emilia sonchifolia in all treated groups thus suggesting the hypolipidemic activities of quercetin and Emilia sonchifolia in cadmium induced oxidative stress.