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QALY (one case) were also apparent. In contrast, the input parameters were quite different. Every analysis demonstrated cost-reduction and patient safety enhancement but methodological differences were present in terms of perspective, discounting, duration, inflation, sensitivity, inputs and definitions (e.g. definition of ADE). Conclusion The different outcome data types used in studies counter the intention to prove the cost-effectiveness of CPOE systems. It is clear that no generally accepted definition is present over which system can be called CPOE. On the other hand, it will only be possible to compare different CPOEs if common agreement is developed in terms of outcomes observed by studies. Clinical pharmacists can play an important role in the unification of the upcoming studies and collection of data. REFERENCES AND/OR ACKNOWLEDGEMENTSThanks to the help of my co-workers and the guidance of our leaders.No conflict of interest.