No abstract

Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (CI).RESULTS: The AA genotype and allele of rs4680 (COMT) appear to be inversely associated with risk of prostate cancer in models adjusted for African men (OR: 0.26 (95% CI 0.08 to 0.83), p ¼ 0.003) and Afro-Caribbean (OR: 0.53 (95% CI 0.32 to 0.86), p ¼ 0.04). For the A allele, a significant inverse association was observed among the cases of low-grade Gleason scores and localized clinical stage, in both populations. The long repetitions (TA) n (n> 6) rs8175347 (UGT1A1) were significantly associated with high grades (OR: 1.41 (95% CI 1.00 to 2.00)) and advanced clinical stage cancer prostate (OR: 1.56 (95% CI 1.02 to 2.37)) in Afro-Caribbean men.CONCLUSIONS: Our results support the hypothesis that polymorphisms of genes encoding enzymes involved in the metabolism of oestrogen to modulate the risk of prostate cancer in populations of African origin.