SummaryThe enantiomers of eight O,O-dialkyl-2-benzyloxycarbonyl-aminoarylmethyl-phosphonates are directly separated on an N-(3,5-dinitrobenzoyl)leucine (DNBleu) column. The influence of the mobile phase composition and the column temperature on the retention and the enantioselectivily are investigated. The influence of the length and steric hindrance of alkoxyl groups of the phosphonate ester and the nature of the substituent p-CI and pH on the benzene ring which is attached to the chiral carbon atom on chiral separation are discussed also.

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