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Artigo / Article REVISTA BRASILEIRA DE HEMATOLOGIA E H E M O T E R A P I A REVISTA BRASILEIRA DE HEMATOLOGIA E H E M O T E R A P I A Hematology Division, Department of Internal Medicine, Medical School of Ribeirão Preto, University of São Paulo Correspondence: Eduardo Magalhães Rego Medical School of Ribeirão Preto, University of São Paulo Hematology Division, Department of Internal Medicine, Medical School of Ribeirão PretoAv. Bandeirantes 3900 14049-900 -Ribeirão Preto-SP -Brazil Phone: 55-16-3602-2888; Fax: 55-16-3633-6645 E-mail: emrego@hcrp.fmrp.usp.br The reciprocal translocation involving chromosomes 15 and 17 [t(15;17) (q22;q21)] is associated with acute promyelocytic leukemia (APL) and leads to the fusion of the retinoic acid receptor α (RARα ) and promyelocytic leukemia (PML) genes thus generating the PML/RARα hybrid gene.

Regardless of the triggering event(s), KC, MIP-2 and integrins participate in TRALI pathogenesis, whereas PAF is essential for capillary leakage when two events are involved.