Segmental aplasia of the paramesonephric (Mllerian) duct (SAP) is an infrequently reported cause of infertility, with few cases reported in North America in the last 30 years. The objectives of this paper are to report the findings and outcome of 17 Holstein Friesian cows recently diagnosed with this condition, and to review and discuss the current genetic and economic considerations in managing this condition in breeding dairy cattle. The possible genetic basis of this condition in the Holstein and other breeds is reviewed, as are the possible molecular aetiologies. Management challenges and options are discussed, as are the needs for centralized reporting and elucidation of SAP in North American Holsteins.
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