The serum of a Wr(a+) woman has becn found to contain an antibody reacting with an antigen of very high incidence. Preliminary tests on the rtrcngth of the Wra antigen on the cella of the antibody forma and the variation of reactions of the antibody with the cells of nonrelated Wr(a+) and Wr(a-) individuals suggest that the antibody may be detecting the antithetical antigen to Wra.
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