Python is an open, general-purpose programming language that is used in many tools, libraries and APIs for Building Performance Simulations (BPS). Advantages of Python in the context of digital twins are the simple and powerful capabilities to generate input files, automate processes, import libraries in many languages and a large number of useful modules. However, in order to use BPS tools and libraries with real time data, a comprehensive data model is required in which all necessary data such as geometry, system engineering, databases, sensors, or simulation parameters for the different BPS are defined. Python in combination with SIMULTAN as a suitable open Building Information Modelling (BIM) data model allows an effective use of these tools and libraries to perform and automate analyses. This paper presents a Python module that integrates the SIMULTAN model in Python and enables almost seamless integration with minor adaptations to existing tools or modules. The import is achieved using simple text-based templates for the data types and their mapping in the data model. The data model, the definition of the data types and the use of this module is demonstrated by calculating the trend of the CO2 concentration in a zone of a digital twin using real time data.