Oxytocin, a hormone exerting controlling effects on lactation, sexual and maternal behavior, and cyclic organization of sleep and wakefulness, is capable of significantly modulating reactions of the organism to the action of stressogenic stimuli. We studied the effects of injections of synthetic oxytocin on the behavioral phenomena and emotional state of rats during realization of a proconflict test induced by "punishments" (nociceptive electrical stimuli) in the process of drinking after water deprivation. Intraperitoneal injections of oxytocin in a 4.0 µg dose resulted in shortening of the delays of coming of rats to a water dish and also in an increase in the number of drinks of water punished by electrical stimulation, as compared with the corresponding indices in control animals. After oxytocin injections, the intensity of research activity of rats in the open field, in general, increased. After realization of the proconflict test, locomotor and orientational/ research activities in animals preliminarily injected with oxytocin were much more intense than those in control rats (in the latter ones, these activities were sharply suppressed). Injections of oxytocin also led to certain normalization of the emotional state; after the proconflict test, negative shifts in this state in control rats were obvious. Therefore, oxytocin appreciably increases the resistivity of the organism against stress.

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In the present study, we examined the effect of an acoustic range of electric-magnetic field (EMF) on the behavioral manifestation of seizure in genetically epilepsy-prone rats (GEPRs) of Krushinsky-Molodkina strain. A 5-days exposure to EMF (10000 -15000 Hz frequency, 1,5 m/Tesla, during 20 min) resulted in partial or complete suppression of behavior seizure activity in GEPRs. Besides, on the background of EMF, the latency period of the first wild run was increased. On the same conditions, duration of wild run decreased. Audiogenic stimuli obtained in GEPRs changed the ECoG activity of sensomotoral cortex only in audiogenallykindled animals. Findings of this study suggest that the regulation of the behavioral manifestation of seizure in GEPRs does not involve the cortex; it is mainly regulated by brainstem structures. We concluded that acoustic range of EMF could apply for suppression of behavioral manifestation of the seizure. Audiogenic stimuli obtained in GEPRs changed the ECoG activity of sensomotoral cortex only in audiogenally-kindled animals. Findings of this study suggest that the regulation of the behavioral manifestation of seizure in GEPRs does not involve the cortex; it is mainly regulated by brainstem structures. Rostral part of the cortex has a significant role in the manifestation of seizure activity in audiogenly kindling GEPRs. We concluded that acoustic range of EMF could apply for suppression of behavioral manifestation of the seizure.

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