Hepatic malignancies have historically been treated with surgical resection. Due to the shortcomings of this technique, there is interest in other, less invasive, treatment modalities, such as microwave hepatic ablation. Crucial to the development of this technique is the accurate knowledge of the dielectric properties of human liver tissue at microwave frequencies. To this end, we characterized the dielectric properties of in vivo and ex vivo normal, malignant and cirrhotic human liver tissues from 0.5 to 20 GHz. Analysis of our data at 915 MHz and 2.45 GHz indicates that the dielectric properties of ex vivo malignant liver tissue are 19 to 30% higher than normal tissue. The differences in the dielectric properties of in vivo malignant and normal liver tissue are not statistically significant (with the exception of effective conductivity at 915 MHz, where malignant tissue properties are 16% higher than normal). Also, the dielectric properties of in vivo normal liver tissue at 915 MHz and 2.45 GHz are 16 to 43% higher than ex vivo. No statistically significant differences were found between the dielectric properties of in vivo and ex vivo malignant tissue (with the exception of effective conductivity at 915 MHz, where malignant tissue properties are 28% higher than normal). We report the one-pole Cole-Cole parameters for ex vivo normal, malignant and cirrhotic liver tissue in this frequency range. We observe that wideband dielectric properties of in vivo liver tissue are different from the wideband dielectric properties of ex vivo liver tissue, and that the in vivo data cannot be represented in terms of a Cole-Cole model. Further work is needed to uncover the mechanisms responsible for the observed wideband trends in the in vivo liver data.

The development of ultrawideband (UWB) microwave diagnostic and therapeutic technologies, such as UWB microwave breast cancer detection and hyperthermia treatment, is facilitated by accurate knowledge of the temperature- and frequency-dependent dielectric properties of biological tissues. To this end, we characterize the temperature-dependent dielectric properties of a representative tissue type-animal liver-from 0.5 to 20 GHz. Since discrete-frequency linear temperature coefficients are impractical and inappropriate for applications spanning wide frequency and temperature ranges, we propose a novel and compact data representation technique. A single-pole Cole-Cole model is used to fit the dielectric properties data as a function of frequency, and a second-order polynomial is used to fit the Cole-Cole parameters as a function of temperature. This approach permits rapid estimation of tissue dielectric properties at any temperature and frequency.

We propose a new method to study high temperature tissue ablation using an expanded bioheat diffusion equation. An extra term added to the bioheat equation is combined with the specific heat into an effective (temperature dependent) specific heat. It replaces the normal specific heat term in the modified bioheat equation, which can then be used at temperatures where water evaporation is expected to occur. This new equation is used to numerically simulate the microwave ablation of bovine liver and is compared to experimental ex vivo results.

Abstract-We present a computational study comparing the performance of narrowband (NB) microwave hyperthermia for breast cancer treatment with a recently proposed ultra-wideband (UWB) approach. Space-time beamforming is used to preprocess input signals from both UWB and NB sources. The train of UWB pulses or the NB sinusoidal signals are then transmitted simultaneously from multiple antennas into the breast. Performance is evaluated using finite-difference time-domain electromagnetic (EM) and thermal simulations with realistic numerical breast phantoms derived from magnetic resonance images (MRIs) of the breast. We use three methods of mapping MRI data to complex permittivity data to account for uncertainty in the embodiment of the dielectric properties transitions in heterogeneous breast tissue. EM power-density deposition profiles and temperature profiles are compared for the UWB and NB cases in the three different breast phantoms. Dominant mechanisms that influence the efficacy of focusing UWB and NB signals in the breast are identified. The results of this study suggest that, while NB focusing performs reasonably well when the excitation frequency is optimized, UWB focusing consistently performs better, offering the potential for tighter focusing and greater reduction of hot spots, particularly in breast tissue, which exhibits distinct dielectric-properties boundaries within the tissue heterogeneity.Index Terms-Breast cancer, electromagnetic (EM) hyperthermia, finite-difference time-domain (FDTD) method, microwave imaging, space-time beamforming, ultra-wideband (UWB) radar.

We measured tissue temperature changes during ex vivo microwave ablation (MWA) procedures for bovine liver tissue. Tissue temperature increased rapidly at the beginning of the MW power application. It came to a plateau at 100 degrees C to 104 degrees C before it increased again. We split the changes of tissue temperature versus time into four phases. This suggests that tissue temperature changes may be directly related to tissue water related phenomena during MWA, including evaporation, diffusion, condensation and tissue water composition. An additional analysis indicated the lesion boundary at approximately 50 degres C to 60 degrees C temperature. We also measured the water content of ablated tissue lesions and examined the relationship of tissue water content and tissue temperature by mapping temperature to remaining tissue water after ablation. The results demonstrate significant tissue water content changes and lead to a better understanding of tissue water movement.