A tin dioxide (SnO 2) sensor was fabricated by inkjet printing onto polyimide foil. Gold electrodes and heater were printed on each side of the substrate. A SnO 2 based ink was developed by sol-gel method and jetted onto the electrodes. A final annealing at 400°C compatible with the polymeric transducers allowed to synthetize the SnO 2 sensing film. Electrical measurements were carried out to characterize the response of the fully printed sensors under oxidizing and reducing gases. The device was heated up at a temperature between 200 and 300°C using the integrated heater. The proper operation of the full printed metal-oxide gas sensors was validated under exposure to carbon monoxide and nitrogen dioxide, in dry and wet air.
The deformability of circulating leukocytes plays an important role in the physiopathology of several diseases like sepsis or acute respiratory distress syndrome (ARDS). We present here a microfluidic method for the passive testing, sorting and separating of non-adherent cell populations by deformability. It consists of microfluidic sieves in series with pore sizes decreasing from the upstream to the downstream. The method capabilities are demonstrated with monocytic cell lines (THP-1) treated by Jasplakinolide (a stabilizer of polymerized actin), LatrunculinA (an inhibitor of actin polymerization), and with the plasma of patients suffering from ARDS. Simple sample injection with standard syringes and pumps makes the method readily adapted for experimentation in hospitals.
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