Abstract:Vaccination is a crucial approach to eradicate and control a myriad of infectious and non-communicable diseases. Subunit vaccines are considered the most convenient approach for vaccine formulation; however, the development of new adjuvants and vaccine delivery vehicles to improve the immunogenicity of such formulations is needed. The authors of this review describe the recent application of porous silicon particles (PSiP) as both a potential vaccine delivery vehicle and adjuvant. PSiP are attractive for this application due to its safety, biodegradability and compatibility for functionalization. Herein, the development of multi-epitope cancer vaccines is discussed as an example on how PSiP are promising materials for the development of innovative vaccines.