An experimental model of cobalt-induced epilepsy was performed on 15 cats. 3 months later, they were irradiated by means of a gamma source with a total target dose of 10 Gy. One month after irradiation all EEG recordings returned to normal, while a control group maintained the epileptiform traces. Histological study of the irradiated foci showed neuronal reafferentation. The action mechanism of ionizing radiation over epileptogenic foci in relation to this reafferentation and neuronal plasticity mechanisms is discussed.

An experimental model of chronic epilepsy has been developed in cats by means of placing cobalt oxide powder epidurally on the left frontal lobe. Radiosurgery of the epileptic focus with a total dose of 10 Gy was performed in a group of 6 animals, and behaviour and EEG observed.