Objective To compare the effectiveness of a nuchal scan at 10 to 14 + 6 weeks and a detailed morphology scan at 12 to 14 + 6 weeks in screening for fetal structural abnormalities. November 2004, 8811 pregnant women were randomized into either the control group (10 to 14 + 6-week nuchal scan followed by routine 16-23-week scan) or the study group (10 to 14 + 6-week nuchal scan and 12 to 14 + 6-week detailed scan followed by routine 16-23-week scan). Methods From March 2001 to ResultsWe analyzed 7642 cases of singleton pregnancies with viable fetuses at first-trimester ultrasound examination and with known pregnancy outcome. In the control group, the detection rate of structural abnormalities in the first trimester was 32. 8% (21/64; 95% CI, and the overall detection rate was 64.1% (41/64; 95% CI,). In the study group, the detection rate in the first trimester was 47.6% (30/63; 95% CI,) and the overall detection rate was 66.7% (42/63; 95% CI,

Objective To evaluate the use of placental volume measured by three-dimensional (3D)