Five pregnant women with a child affected by spinal muscular atrophy (SMA) were recruited between November 2014 and March 2015. Deletion of exons 7 and/or 8 in the SMN1 gene were identified by multiplex ligation-dependent probe amplification (MLPA), the current standard diagnostic test for SMA. Parental and fetal haplotypes of the SMN1 gene were determined in each family from haplotype-based non-invasive testing of blood samples and maternal plasma, respectively. Fetal haplotype was compared with the results of MLPA of fetal DNA obtained from amniotic fluid or chorionic villi. Parental haplotypes were constructed successfully in the five families. Assisted by the information on parental haplotype, non-invasive testing of maternal plasma identified one fetus with homozygous deletion of exons 7 and 8, two fetuses with heterozygous deletion of exons 7 and 8 and two normal fetuses. These results were consistent with the diagnosis by MLPA. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.

rate near to 0%. The main problem was the pcr processing time. For the sake of convert recovery rooms to ICU beds, Caesarean recoveries were done in labour room. 68 patients were benefited (97%, rest were COVID-19 positive or unknow). None reinterventions or problems with pain management were detected. Also skin-to-skin contact between mother and neonates after caesarean were possible. As a way of minimising hospital stay and potential virus exposure an early discharge (24 hours postpartum) puerperal pilot program was launched. Strict mother and neonatal conditions must being fulfilled. 10 woman and their neonates could adhere to program. No readmissions were registered. Only one visit to emergencies due to normal uterine bleeding. 14 hospital stay were saved. Creation of a telephonic 24h number for COVID-19 and pregnancy relation doubts with more than 80 phone calls attended. A no on-site medical consultation was implanted. This allowed the attention and follow up of 4 patients COVID-19 and isolated and home in combination with GP, allowing a proper fit of all varying management protocols. Same team were designed to attend pregnancy who were hospitalised. Conclusions: Pandemic had supposed deep organisation changes, but, this hard moments have serves to learn and they come to stay.