NCT01494558.

Radiation therapy of NPC patients may lead to cranial neuropathy. Patients with facial–cervical radiation fields had a longer latency for the manifestation of CNP compared with those patients who were treated with split fields. In patients with re-radiotherapy, the frequency of upper cranial nerve injury increased greatly.

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group, with 100 cases in each. The median OS of the two groups were 36 months vs 26 months and 5-year OS rates were 36.2% vs 20.3%, respectively (PZ0.011). The median CSS were 36 months versus 27 months and 5-year CSS were 38.5% vs 21.1%, respectively (PZ0.010). Univariable analysis showed that only PORT significantly improved OS (HRZ0.648, PZ0.013) and CSS (HRZ0.639, PZ0.012). Multivariable analysis confirmed that PORT was the only significant predictor of OS (HRZ0.615, PZ0.011) and CSS (HRZ0.614, PZ0.013). Conclusion:For patients with ypN2 NSCLC after NCS, PORT can significantly improve the OS and CSS . However, the result needs to be clarified by prospective randomized clinical trials.

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