Cyclosporin A is a fungal metabolite whose inhibitory effect is on T lymphocytes and in particular on cells mediating rejection of allografts. Evidence suggests that it may be more effective than conventional immunosuppressive treatment in recipients of organ transplants.' Successful pregnancies have been reported in allograft recipients receiving cyclosporin daily from conception to delivery.2 3 We describe the clinical course of a pregnancy in a renal allograft recipient receiving cyclosporin A in which the fetus was growth retarded; we also review other such pregnancies.Case report