This exploratory, multicentre, fast-track laparoscopic liver resection study is the first such study conducted. Although small, the study suggests that a multimodal enhanced recovery programme in laparoscopic liver surgery is feasible, safe and may lead to accelerated functional recovery and reductions in LOS.

Large-amplitude sleep slow oscillations group faster neuronal oscillations and are of functional relevance for memory performance. However, relatively little is known about the impact of slow oscillations on functionally coupled networks. Here, we provide a comprehensive view on how human slow oscillatory dynamics influence various measures of brain processing. We demonstrate that slow oscillations coordinate interregional cortical communication, as assessed by phase synchrony in the sleep spindle frequency range and cross-frequency coupling between spindle and beta activity. Furthermore, we show that the organizing role of slow oscillations is restricted to circumscribed topographical areas. These findings add importantly to our basic understanding of the orchestrating role of slow oscillations. In addition, they are of considerable relevance for accounts of sleep-dependent memory reprocessing and consolidation.

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The sleeping brain retains some residual information processing capacity. Although direct evidence is scarce, a substantial literature suggests the phase of slow oscillations during deep sleep to be an important determinant for stimulus processing. Here, we introduce an algorithm for predicting slow oscillations in real-time. Using this approach to present stimuli directed at both oscillatory up and down states, we show neural stimulus processing depends importantly on the slow oscillation phase. During ensuing wakefulness, however, we did not observe differential brain or behavioral responses to these stimulus categories, suggesting no enduring memories were formed. We speculate that while simpler forms of learning may occur during sleep, neocortically based memories are not readily established during deep sleep.

The objective of this work was to create Co-based coatings (compositionally close to Stellite 6) on compacted graphite and gray cast iron substrates with a high power laser (2 kW continuous Nd:YAG) cladding process. The relationships between the relevant laser cladding parameters (i.e. laser beam scanning speed, laser power and powder feeding rate) and the main geometrical characteristics of a single laser track (height, width, dilution, etc.) were examined. A gradual variation of a single processing parameter was used for an appropriate experimental analysis and statistical correlations study between main processing parameters and geometrical characteristics of an individual laser track. These relations lead to the design of a laser cladding processing map that can be used as a guideline for the selection and further tuning of proper processing parameters for laser cladding of extensive layer. The coatings with thickness from 1.0 to 3.3 mm were created on flat substrates without cracks and other major defects. The microstructural features of these coatings were studied using optical microscopy, scanning electron microscopy (Philips XL30 FEG), EDS (EDAX) and XRD. Mechanical properties were determined using microhardness measurement, scratch test (CSM Revetest) analysis at room temperature and using the tribotesting (CSM HT Tribometer) at room and elevated (up to 525°C) temperatures.