Increased levels of homocysteine (HCYS) represent a risk factor for a series of physiopathological conditions: mental retardation, cardiovascular and neurodegenerative diseases, Parkinson's and Alzheimer's disease, depression, osteoporosis, endothelial dysfunction and inhibition of cell proliferation. This paper aims to present the pathophysiological implications of HCYS and the correlation of hyperhomocysteinemia (H-HCYS) with critical condition in the intensive care unit (ICU). Hypovitaminosis B and folate deficiency is directly involved in the inhibition of HCYS metabolism and the accumulation of HCYS in the plasma and tissues. Critically ill patients are more prone to H-HCYS due to hypermetabolism and accelerated synthesis produced by reactive oxygen species (ROS). In conclusion it can be affirmed that the determination and monitoring of HCYS plasma levels may be of interest in optimizing the therapy for critically ill patients. Moreover, by controlling HCYS levels, and implicitly the essential cofactors that intervene in the specific biochemical pathways, such as vitamin B6, vitamin B12 and folic acid can provide a diversified and personalized treatment for each patient.

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The paper presents a study regarding electro-hydraulic control systems for drive winches, a structural part of LARS (Launch and Recovery Systems). In the Introduction section of the paper, the authors present the domains of the research vessel. Furthermore, there is presented the importance of launch and recovery systems (LARS) and drive winches on the deck of a research vessel. The launch and recovery systems (LARS) using drive winches are installed on the stern of the research vessel. Further in the paper, the authors present the results of studying three simplified systems that use electric, hydraulic and electro-hydraulic driving solutions. Furthermore, there are presented comparative advantages of using this three types of drive winches. At the end of the paper, the authors perform an analysis of the electro-hydraulic systems for the drive winch, using a modelling and simulation software. Each schematic is presented along with its components. Moreover, the authors mention that all the schematics presented in this paper are modelled using FluidSim software from FESTO. In this case, only three mathematic relations are used in the paper: the Cauchy momentum (convective form), the incompressible Euler relations and the pressure losses in the hydraulic and electro-hydraulic drive winch.

The paper is focused on the architecture and design of a wind tunnel for measurement of aerodynamical resistances. The quantities which influence the flow of fluids and the applied laws in this case are described on short. Taking into account the main criteria for wind tunnels classification (architecture, test chamber type, test chamber fluid speed) type of the tunnel will be chosen fallowed by the design and construction. Test chamber measurements are carried on by an anemometer. The physical results are compared with the modelling results obtained for ideal conditions with the aid of SolidWorks software.

In freight transport is constantly evolving in the world. An important role in development of freight transport is the increasing usually a speed to 180 km/h of freight trains. In multimodal transport, all the goods are transported in containers. Therefore, the freight is mostly containerized. Several containers in freight trains are transported on Rgs freight wagons. On Rgs platforms of freight wagons are bolts of which the containers are fixed. The role of these bolts is very important because when the train takes the curve or brakes ward, containers could leave the wagon’s platform. In this paper, we represented a Rgs Wagon loaded with two containers. We have to mention that the dimensions of wagon and containers have been made using original projects. Furthermore, we are approached the theoretical aspects referring to the clamping system. We set out to accomplish a through search of both the used bolt to Rgs wagons and new model of bolt. This research was caried out with the help of finite elements method. The design part and the study with finite elements were made in NX 12 software from Siemens. Because of these bolts types they following stress: normal, shear and von Mises. As a consequence, we deduced that the second bolt type is more reliable.