Summary Background We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Methods In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Results Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p<0.001; B: p<0.001, C: p<0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p <0.001; C: p<0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p<0.001, p<0.01), IL-6 lower (p<0.05, p<0.001), while homocysteine levels turned out to be similar to controls. Conclusions AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP

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Introduction: Acute myocardial infarction (AIM) is ischemic myocardial necrosis and is associated with a number of adverse outcomes that complicate patient health care. Assessment of patient status, risk factors, and adverse outcomes has a significant impact on patient care planning after AIM. The GRACE (Global Registry of Acute Coronary Events) score is of great importance in risk stratification in these patients. Objective: To determine the importance of determining the GRACE score in order to set priorities in the planning of patient care after acute myocardial infarction. Method: A retrospective study examined 50 patients, both sexes, aged 28 to 75 years, with a diagnosis of acute myocardial infarction, undergoing percutaneous coronary intervention (PKI), who were treated at the Zvezdara Clinical Hospital in Belgrade during the research period, from January to March 2020. Data were taken from the medical records of these patients. During the study, AIM type, comorbidities, CVD risk factors, GRACE score and frequency of complex nursing interventions in patients with low, moderate, and high-risk of adverse cardiac events were monitored. Results: Out of a total of 50 examinees with AIM treated with PKI, 74% had STEMI and 26% NSTEMI. 84% of patients had positive family history, 64% hypertension, 2% diabetes, 48% obesity, 52% were smokers and 6% of them were using alcohol. The values of the GRACE score were increased as follows: in four patients more than 140, while in one of them a moderate value was recorded, and in one low value of the GRACE score. In the course of six months, three patients, who had high GRACE scores on hospitalization, had a lethal outcome. Complex nursing interventions in the intensive care unit are more common in patients who have high GRACE score values after AIM. Conclusion: The GRACE score can be used as an important guideline in planning the health care of patients after an acute myocardial infarction.

Introduction: Acute coronary syndrome manifests as STEMI and NSTEMI acute myocardial infarction (AIM). Adverse cardiovascular events include: heart failure, nonfatal reinfarction, recurrent angio pain, rehospitalization, and mortality. The SYNTAX score is an angiographic indicator that is a predictor of adverse events after AIM. The aim of this study was to determine the significance of Syntax score as a predictor of adverse outcomes in patients after acute myocardial infarction. Method: A retrospective study was conducted at the Zvezdara Clinical Hospital in Belgrade in the Department of Interventional Cardiology, by analyzing medical documentation for the period January - March 2020. 80 patients of both sexes, aged 30 to 80, were examined and hospitalized for myocardial infarction. The monitored parameters were: socioepidemiological data, SYNTAX score, adverse events (recurrent infarction, revascularization, stroke and mortality). Results: Of the 80 respondents included in the study, 32.5% were female and 67.5% male. 75% of them had STEMI and 25% NSTEMI entity. The average age of the patients was 61.7 years. Adverse events one year after hospitalization were present in 40% of patients with STEMI, namely: reinfarction in 6.7%, revascularization in 23.3%, stroke in 1.7% and lethal outcome in 8.3% of patients. SYNTAX score is low in 24 patients (40%) with STEMI myocardial infarction and high SYNTAX score in 25 subjects (41.6%). Conclusion: The SYNTAX score as a predictor of adverse outcomes is extremely important for clinical practice and follow-up of patients after acute myocardial infarction.

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