Objectives Behçet's disease (BD) is a type of systemic vasculitis and inflammatory disease of unknown etiology, which is associated with fatigue and lower quality of life (QoL). The aim of this study was to assess the relationship between Behçet's Disease Current Activity Form (BDCAF) and Behçet's Disease Quality of Life (BDQoL), depression, anxiety and fatigue in Behçet's disease. Methods We conducted a cross‐sectional study of 155 BD patients and 107 healthy subjects in a single center over a 1 year period. All participants completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, and the Hospital Anxiety and Depression (HADS) scale. Disease activity in the BD patients was assessed using the BDCAF, and the physician's global assessment (PGA). BD patients also completed the BDQoL questionnaire. Results There was no significant difference in age and gender between the groups. BD patients had significantly higher HADS‐anxiety (HADS‐A), HADS‐depression (HADS‐D) and MAF scores than the healthy control group (P < 0.05). BD patients with active disease had significantly higher MAF and HADS‐A scores compared to inactive BD patients (P < 0.05). MAF scores showed positive correlations with HADS‐A, HADS‐D, BDCAF and BDQoL. Conclusions Fatigue and anxiety are common in clinically active BD patients compared with healthy control subjects and inactive BD patients.

Higher IL-20 levels in active BD patients, when compared to inactive BD patients and healthy controls indicate that the disease is an inflammatory one and IL-20 plays a role in the disease pathogenesis. Moreover, it can be concluded that IL-20 might have a role in the complex process of the settlement and activation of the disease.

Introduction: Behçet's disease (BD) is a relapsing systemic inflammatory disorder. The diagnosis of BD is primarily based on clinical findings. Current biomarkers are not yet sufficient to diagnose and cannot anticipate the course of the disease and response to treatment. The aim of this study was to evaluate the relationship between the thiol-disulfide balance and disease activity and organ involvement in BD. Material and methods: A hundred fifty patients with BD and 100 age-and gender-matched healthy controls were included in the study. Disease activity was assessed with the BD Current Activity form score. Serum levels of native thiol (NT), total thiol (TT), and disulfide were measured and the disulfide/native thiol, disulfide/total thiol and native thiol/total thiol levels were calculated for the patient and control groups. Results: Native thiol, total thiol, native thiol/total thiol values of the BD patients were significantly lower than those of the control group. The disulfide/native thiol, disulfide/total thiol values of BD patients were higher compared to the control group and the disulfide value of the BD group was slightly higher compared to the control group. No correlation was determined between thiol levels and disease activity and organ involvement in BD. Conclusions: In patients with Behcet's disease, the thiol-disulfide homeostasis balance shifted towards disulfide formation due to thiol oxidation. It may be used as a novel marker in BD because it is easy, practical, fully automated and relatively inexpensive.

BackgroundBehçet’s disease (BD) is a type of systemic vasculitis and inflammatory disease with unknown etiology which is associated with fatigue and lower quality of life (QoL).1 ObjectivesIn this study we aimed to assess the relationship between BDCAF and BDQoL, depression, anxiety and fatigue in Behçet’s disease.MethodsThis is a cross-sectional study of 155 Behcet’s syndrome (BS) patients and 107 healthy controls in Turkey. All subjects completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, Hospital Anxiety and Depression (HADS) scale. Disease activity among BS patients was assessed using the Behçet’s Disease Current Activity Form (BDCAF), and the physician’s global assessment (PGA). And BD patients completed the Behçet’s Disease Quality of Life (BDQoL) questionnaire.ResultsThere was no significant difference with age and gender between the groups. BS patients had significantly higher HADS-anxiety (HADS-A), HADS-depression (HADS-D) and MAF scores than the healthy controls (p<0.05) (table 1). BS patients with active disease had significantly higher MAF and HADS-A scores compared to inactive BS patients (p<0.05). MAF scores showed positive correlations with HADS-A, HADS-D, BDCAF and BDQoL (table 2).Abstract FRI0513 – Table 1Comparison of BS patients and healhy controlsPatientsHealty controlsp BDCAF2.7±1.6-BDQoL9.4±9.2-HADS-Anxiety67 (%43.2) 11 (%10.3)0.001HADS-AnxietyScore8 (0–21) 6 (0–13)0.004HADS-Depression63 (%40.6) 23 (%21.5)0.001HADS-Depression Score5 (0–20) 4 (0–10)0.340MAF25.0 (6.5–48) 19.2 (7.3–44.2)0.000Abstract FRI0513 – Table 2Corelations between MAF score and BDCAF, BDQoL, HADS-A, HADS-D in BS patientsParametreMAF score Rp HADSD0459<0001HADSA0548<0001BDQoL0572<0001BDCAF0359<0001DrVAS0285<0001Patient VAS0434<0001Age01190141Disease duration00700384ConclusionsFatigue and anxiety is common in clinically active BS patients compared with healthy controls and inactive BD patients.Reference[1] Tascilar NF, Tekin NS, Ankarali H, et al. Sleep disorders in Behcet’s disease, and their relationship with fatigue and quality of life. J Sleep Res2012;21(3):281–288.Disclosure of InterestNone declared

BackgroundIt's a known fact that serum levels of the tumor necrosis factor Alfa (TNF-α) interleucin-6 (IL-6) and other proinflammatory cytokines which are released from the adipose tissue are increased in Behcet's disease (BD). In BD adipose tissue is not a passive energy depot, it is an active endocrine organ and releases adipositokines. Visfatine is one of them. Visfatin is related to TNF-α and IL-6, IL-1 beta, co-stimulators like CD40, CD54, CD 80 and endothelial ICAM-1 and ICAM-2. We aimed to search the relation among levels of serum visfatin in BD activity.Methods60BD patients (30 in active state and 30 in remission) who were diagnosed according to The Criteria of Working Group on International BD and 20 healthy subjects as controls were involeved in to the study. Serum visfatin levels were compared in between three groups.ResultsVisfatin levels were significantly higher in both group of patients compared to the healthy control group (both p<0,001). Serum visfatin levels in active state patients were higher than those in inactive state (p<0.001). The same way in all cases statistically significant correlation between visfatin and CRP (p<0.001) and visfatin and ESR (p<0.01). According to the symptoms of the patients in the active state, patients with genital aphtous ulcers had higher serum visfatin levels than the active patients without genital aphthous ulcers (p<0,001).ConclusionsSerum visfatin levels in BD patients with active and inactive states are higher than the healthy control group. That could be concluded as visfatin as a proinflammatory cytokines have a role in chronic inflammatory reactions and sustains the cellular expression of the inflammatory cytokines in BD.ReferencesSamara A, Clin Endocrinol (Oxf). 2008;29.Moschen AR, J Immunol. 2007;178:1748-1758.Yazici H, Curr Opin Rheumatol. 2001; 13:18-22.Sahin M, Ann Clin Lab Sci. 2006; 36:449-454.Moschen AR, J Immunol. 2007;178:1748-1758. 6- Samara AClin Endocrinol (Oxf). 2008;29.Disclosure of InterestNone declared