No abstract

QUAD-Shot palliative radiation therapy coupled with radiosensitizing chemotherapy is efficacious and well-tolerated in patients with newly-diagnosed or recurrent head and neck cancer not amenable to curative therapy.

Mice with miR-21 loss demonstrated delay in spontaneous tumor formation, decreased growth rate, and reduced macroscopic lung metastases compared to MMTV-PyMT mice with intact miR-21. When challenged with orthotopic tumor implantation, miR-21+/and miR-21-/-mice had increased delay in allograft tumor formation compared to wild-type mice, suggesting stromal changes in the mammary microenvironment modulated by miR-21. Conclusion: Modulation of miR-21 expression in a murine tumor model appears to play an important role in breast cancer tumorigenesis and progression. Expression of miR-21 may be linked to treatment resistance and development of an aggressive tumor phenotype. As modulation of miR-21 appears to delay de novo tumorigenesis as well as tumor allograft formation, multiple mechanisms of tumorigenesis may be implicated. Targeted inhibition of the miR-21 pathway may be an attractive therapeutic option to both sensitize tumors to cytotoxic treatment while modulating the peritumoral stroma.

SNUC is an aggressive malignancy with a high tendency to metastasize. Better outcomes were obtained with a trimodality approach. Modern radiotherapy (RT) techniques and doses ≥ 60 Gy were associated with improved OS.