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When BALB/c mice bearing growing transplants of a syngeneic colon carcinoma--Colon Tumor 26 (CT 26)--were treated with Bacillus Calmette-Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development of lung metastases was noted in the BCG-treated mice, resulting in both as increased mortality rate (from metastatic disease) and a shorter survival time.

Differentiation of Trypanosoma brucei in the mammal limits the degree of parasitemia and prepares the trypanosome tor passage back into the tsetse fly. In an attempt to define the signals that control differentiation, we found that theophylline, in contrast to indomethacin, blocked differentiation, prolonged parasitemia, elevated prostaglandin and cyclic AMP concentrations of rat plasma, and depressed intratrypanosomal cyclic AMP. Relatively nontoxic drugs that alter differentiation are powetful tools for elucidating the events that control this important process.

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