A BOY, set 14 years, having in April last sustained severe and extensive burns, under treatment had accomplished the heal¬ ing of them all except certain granulating regions beneath the chin and lower jaw, and the right arm from elbow to fingers. Upon these surfaces skin grafts were finally placed. For the neck grafts were ob¬ tained from the arms ol the father and broth tr of the patient, but for the arm grafts were taken from two young puppies of the Mexican hairless breed, whose soft white hairless skin seemed to offer itself for the purpose with good prospect of successful result.The result was all that could be desired. The puppy-grafts proved to be superior to the human grafts; a greater proportion ot them "took," and their sub¬ sequent rate of growth was much faster.[Note by the Editor.-The above use of puppy-grafts was origi¬ nal with the reporter of the above case, and when he communicated it he was unaware that any similar case had been recorded.In the Lancet, March 15, 1890, however, is reported a similar case by Mr. Alex. Milro, of Edinburg. The case is as follows:A boy, set. 10 years, presented an extensive ulcer on the left leg, re¬ sulting from a burn. The entire surface was covered with healthy granulations, but there was not the slightest attempt at cicatrization. It being impracticable to obtain sufficient human skin to cover the ul¬ cers, a young black and white greyhound, seven days old, was killed with chloroform, and, the whole of his anterior abdominal wall and flanks having been shaved, the flap of the skin thus marked out was dissected up, taking the entire thickness, leaving the subcutaneous fat. The skin was cut into strips measuring six inches long by half an inch broad, which were firmly pressed into the previously cleaned ulcer in the long axis of the limb. Smaller grafts, about an inch square, were used to fill in spaces left between the larger ones. A considerable area
Introduction. It is rare for actinic or squamous cell carcinoma (SCC) in situ to metastasize. Case Presentation. A 67-year-old male had a significant medical history including severe psoriatic arthritis treated with UVB, methotrexate, and rapamycin. He had twenty-five different skin excisions of actinic keratosis four of which were invasive SCC. Our patient developed shortness of breath necessitating a visit to the emergency department. A CT scan of his chest revealed a mass in the right lower lung. A subsequent biopsy of the mass revealed well-differentiated SCC. He underwent thoracoscopic surgery with wedge resection of the lung lesion. Discussion. Actinic keratosis (AK) is considered precancerous and associated with UV exposure. It exists as a continuum of progression with low potential for malignancy. The majority of invasive SCCs are associated with malignant progression of AK, but only 5–10% of AKs will progress to malignant potential. Conclusion. In this case, a new finding of lung SCC in the setting of multiple invasive actinic cutaneous SCC associated with a history of extensive UV light exposure and immunosuppression supports a metastatic explanation for lung cancer.
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