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SummaryThe frequency of antigens HL-A 1 (48%) and in 54 patients with active chronic hepatitis from south-east England was significantly higher than in 89 control subjects from the same region (22% and 17% respectively). No correlation could be detected with the age and sex of the patients or with the presence of a particular immunological abnormality but the frequency of HL-A 1 and HL-A 8 was much lower in the nine patients who were positive for HBAg than in the 45 HBAg-negative cases. These results provide further evidence of the importance of genetic factors in active chronic hepatitis. In contrast the frequency of HL-A 1 and HL-A 8 in primary biliary cirrhosis, both in 45 patients from south-east England and in 28 patients from western Scotland, was not significantly different from that found in control groups from the same regions.

about 25 %. These calculations suggest that the failure rate might be about 2% higher with dose 4 than with dose 1. The observed difference (about 1-5%) was in reasonable agreement.There was evidence of an association between transplacental haemorrhages of 4 ml or more and failures with dose 4. Twelve women had -an estimated transplacental haemorrhage of 4 ml or more after a first pregnancy, and t,here were three additional women with a transplacental haemorrhage of this extent who were excluded from the trial. If Requests for reprints to: M.R.C.

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