ThinPrep ® Pap test is a Liquid Based Cytology (LBC) method, representing the first, after 50 years, evolution of classical Papanicolaou test (Conventional Cytology-CC). This method initiates changes in the way of fixation and production of slides which enhance dramatically the smear quality. Due to this reason, ThinPrep Pap test was authorized in 1996 by the Food and Drug Administration (FDA) of U.S.A. as a replacement to the conventional Papanicolaou test. In ThinPrep, the smears, instead of layering on the glass slides immediately after their extraction form the cervix, they are collected using a sampling device which is rinsed into a vial containing a fixative solution (PreserveCyt ®). The vial is then transported to the cytopathology laboratory where a slide is prepared by specialized modalities that create a single layer of cells on the slide with total area less than 50% comparing to the area of a conventional slide. The remaining biological material in the LBC vial can be used for molecular techniques.