Objective: Assessment of the physiological effects of a diet rich in phosphorus in young women. Design: Control period I Ð commercial basic diet containing 1700 mg P and 1500 mg Caaday for 4 weeks. Supplementation period Ð a 6 week high-phosphorus period of 3008 mg P and 1995 mg Caaday. Control period II Ð 4 weeks washout with basic diet as in period I. Setting: Institute of Nutritional Science, Friedrich Schiller University, Jena. Subjects: Ten healthy women, aged 20 ± 30 y. Interventions: Orange juice and tablets, containing supplements of Ca 5 (PO 4 ) 3 OH and NaH 2 PO 4 , totalling 1436 mg elemental phosphorus per day. Results: There was an increase of 10.7 AE 13.7 pgaml in serum PTH, a decrease of 0.6AE 0.6 ngaml in serum osteocalcin, an increase of 73.6 AE 136.6 nmolammol creatinine in urinary pyridinoline and of 19.3 AE 36.0 nmola mmol creatinine in urinary deoxypyridinoline, and a decrease of 2.6 AE 9.3 mgal in urinary microalbumin. All changes were insigni®cant. There were no changes in serum levels of Ca, PO 4 or Zn, in serum concentration of 1,25-(OH) 2 D 3 , and in urinary b-2-microglobulin excretion. Phosphorus supplementation caused intestinal distress, soft stools or mild diarrhoea. Conclusions: In spite of a high phosphorus supplementation no signi®cant changes in bone-related hormones, pyridinium crosslinks as markers of bone resorption and parameters of renal function in young women were found.

To evaluate the effect of lung transplantation on right ventricular (RV) and left ventricular (LV) volumes and function, magnetic resonance imaging (MRI) was performed in 11 patients before and 6 to 24 months after single (n = 7) or double (n = 4) lung transplantation as well as in 15 healthy control subjects. Prior to transplantation, RV end-diastolic (RVEDVI, ml/m2) and end-systolic (RVESVI, ml/m2) volume indices were significantly increased in patients compared with those in control subjects. RV ejection fraction (RVEF, %), although within the lower normal range, was significantly reduced. In contrast, LV volume indices (ml/m2) were significantly smaller in patients than in control subjects, whereas LV ejection fraction (LVEF, %) was not different from that in normal subjects. After lung transplantation, MRI revealed a significant reduction in RVEDVI from 73 +/- 29 to 54 +/- 14 (p = 0.03) and RVESVI from 38 +/- 23 to 20 +/- 6 (p = 0.01) with a concomitant significant increase in RVEF from 48 +/- 14 to 63 +/- 6 (p = 0.01). Consecutively, the LV expanded to normal (LVEDVI from 49 +/- 12 to 65 +/- 14, p = 0.01; LVESVI from 23 +/- 9 to 28 +/- 7, p = 0.05), whereas LVEF remained unchanged (55 +/- 9 versus 56 +/- 8).

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We report the results of enzyme determinations in sera from 88 patients, 65 of whom showed inconspicuous reconvalescence, 14 who had myocardial infarction within 24 h (MI 1) after bypass surgery, and nine with myocardial infarction between 24 and 48 h postoperatively (MI 2). We wanted to determine whether the consequent measurement of activities of total creatine kinase (CK), CK isoenzyme MB (CK-MB), lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, and aspartate aminotransferase, conducted as a part of routine laboratory diagnostics, provided meaningful information for diagnosing infarcts besides that obtained from the electrocardiogram. The postoperative mean values of the enzyme activities in blood were significantly different among the three groups; however, only a combined evaluation of CK and CK-MB by means of a discriminant analysis allowed the prediction of MI (sensitivity: MI 1 = 98.5%, MI 2 = 95.4%; specificity: MI 1 = 71.4%, MI 2 = 81.8%). CK greater than 600 U/L or CK-MB greater than 45 U/L supports the diagnosis of acute MI.

Our prospective cohort showed a concordance of tumor location and laterality of LN metastasis in BC at RC without any predictive criteria and without any influence on CSM. It is debatable, whether these findings may contribute to a more individualized patient management.