Acute hepatic failure was induced in pigs by a combination of phenobarbitone, reversible hepatic artery ischemia, and low-dose carbon tetrachloride. Plasmaphoresis combined with charcoal or resin plasma perfusion resulted in no significant reduction in arterial amino acid levels despite proven amino acid absorption by the charcoal columns. No prolongation of life was attained in the pigs when compared to nonplasmaphoresed control animals.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.