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Prostate cancer is responsible of a high mortality its prognosis has been improved in recent years thanks to radiotherapy (RT) which is considered the reference treatment for localized or locally advanced stages. However, spreading the RT sessions over almost two months poses problems of fatigue linked to repetitive movements, particularly for the oldest patients, but also of the overall cost of the treatment, including the time of occupation of the machine and transportation. To meet these constraints, other RT regimens have been developed seeking to maintain identical efficacy and toxicity while reducing the total duration of treatment. These so-called hypofractionated protocols use recent techniques of image-guided RT (IGRT) and conformal RT with intensity modulation (IMRT).

Purpose: To retrospectively study our risk factors for breast cancer recurrence and compare them with data from the literature. Materials and Methods: Through the analysis of 310 patients admitted to the radiotherapy department of the Mohammed V Military Teaching Hospital in Rabat between January 2009 and December 2015, we identified local, locoregional and / or systemic recurrence factors. Results: The mean age was 49.15 ± 10.37 years, the mean parity was 3.3 ± 2, 43.5% were postmenopausal, 18.3% had a family history of breast cancer, and 41.3% used oral contraception. According to the TNM classification, 49.8% were classified as stage IIA. Invasive ductal carcinoma was predominant (82.6%). For the histo-prognosis grade of Scarf-Bloom and Richardson (SBR), 91% of patients were classified as SBR II and III. Lymphovascular invasion (LVI) were positive in 44.2%, and hormone receptors (HR) were positive in 75.8%. Lymph node involvement ≥4 nodes was noted in 28.5% of patients. In univariate analysis, the presence of LVI (p <0.001), N≥4 (p <0.025) and RH negative (p <0.021) were statistically significant risk factors for recurrence. While in multivariate analysis, only EV (p <0.035) and HR negativity (p <0.012) were statistically significant. Conclusion: Our study highlights known risk factors; namely massive ganglionic invasion, lymphovascular invasion and hormone receptors.

The aim of this study was to report the experience of Military Teaching Hospital Mohamed V (MTHM V) in the management of NPC treated with volumetric modulated arc therapy (VMAT) Materials and Methods: This is a retrospective study conducted between January 2013 and December 2017. All patients with a nasopharyngeal cancer were included. Patients who had distant metastasis at the time of diagnosis were excluded. The volumetric arc therapy modulation of intensity (VMAT) is the technique radiotherapy used in all our patients. Results: one hundred and one (101) patients with nasopharyngeal cancer were treated in our department. The average age was 42.95±16.36. The predominant histological type is undifferentiated carcinoma (UCNT) in 93 % of cases. Tumors were classified according to the American Joint Committee on Cancer (AJCC) classification of 2010 in Stage I : 1%, Stage II in 10.9%, Stage III in 45.5%, Stage IVa in 32.7% and stage IVb in 9.9%. The treatment consisted of neoadjuvant chemotherapy followedby concomitant radio chemotherapy (RCC) at 79.2 % of patients, an RCC immediately in 12.8 % of cases and 8 % of patients received neoadjuvant chemotherapy followed by exclusive radiotherapy. The therapeutic tolerance was good with 16.8% of acute radiomucite Grade 3, 8.9% of acute dermatitis Grade 3 and no complication Grade 4. The overall survival was 98.8% and 84.8% at 2 and 5 years respectively, and the PFS was 85.6% and 76.8% at 2 and 5 years, respectively. N3 and time to relapse were significant in multivariate analysis for OS. Neoadjuvant chemotherapy and N3 were significant in multivariate analysis for PFS. Conclusion: volumetric modulated arc therapy with concurrent chemoradiotherapy with additional neoadjuvant chemotherapy has good response and outcomes. Our findings are in good accordance with other series but further large studies are warranted to improve prognostic of this potentially curable malignancy.