ABSTRACT.Purpose: To test intrasession, intersession, intervisit and interoperator reproducibility of retinal nerve fibre (RNFL) measurements and retinal thickness in healthy subjects using Cirrus Fourier-domain optical coherence tomography (OCT) (Carl Zeiss Meditec, Inc). Methods: Seventy-two eyes of 72 healthy subjects were included in the study. All the eyes underwent three 512 · 128 volume cube centred on the fovea and three 360°circular scans centred on the optic disc by one observer. This sequence was redone by another observer on a second visit within a 2-week period. Descriptive statistics, analysis of variance, intraclass correlation coefficients (ICCs) and coefficients of variation (COVs) were calculated for the nine areas corresponding to the Early Treatment Diabetic Retinopathy Study and for quadrants and RNFL clock hr sectors. Results: Retinal thickness and RNFL measurements were highly reproducible. Mean total retinal thickness was 285.2 ± 15.3 lm by observer 1 and 284.2 ± 12.9 lm by observer 2. Mean COV was 1.2%. Mean RNFL average thicknesses were 96.0 ± 7.7 and 95.7 ± 7.9 lm by observer 1 and 2, respectively. Mean COV was 4.4%. The ICCs ranged from 0.823 to 0.992. Mean differences between both operators were lower than 3 lm, and no significant differences were found. Conclusions: Retinal and RNFL thickness measurements obtained using Cirrus OCT show good repeatability for healthy eyes and few differences between intra-and interobserver evaluations. It can be considered a valid device for measuring retinal and optic nerve parameters in normal eyes.

IMQ and RT therapies are effective for treating eyelid nodular BCCs. Cosmesis and functional results were better with IMQ, while tolerability was higher with RT.

IMQ therapy is effective for treating periocular BCCs with a cure rate similar to that of surgery. Aesthetic results were rated as excellent. IMQ is a useful alternative to surgery in patients with periocular BCCs when other therapies have failed or are not possible.

Purpose: To evaluate changes in retinal layer thickness in patients with Type 1 diabetes with no diabetic retinopathy after 8 years of follow-up. Methods: Ninety Type 1 diabetes and 60 control eyes were studied. Changes in the retinal nerve fiber layer, ganglion cell layer, and inner nuclear layer thicknesses in all Early Treatment Diabetic Retinopathy Study areas were evaluated. Results: The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control group, respectively. In 2009, total retinal thickness was higher in diabetic patients; differences were statistically significant in all except the nasal areas. In both groups, the mean foveal thickness remained the same during the 8 years. Among diabetic patients, there was a significant reduction in total retinal thickness in all areas excluding the outer temporal one; controls only in the inferior areas. The thickness loss was due to the thinning of the inner retinal layers (inner nuclear layer, ganglion cell layer, and retinal nerve fiber layer). The controls showed a significant diminution in the retinal nerve fiber layer and in the ganglion cell layer areas. The inner nuclear layer showed a diminution in the diabetes mellitus group. Conclusion: Before the onset of diabetic retinopathy, Type 1 diabetes patients experience a diminution of their inner retinal layer thicknesses over time, supporting the hypothesis of retinal neurodegeneration.