Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic inflammation. Neuronal fractalkine (FKN), acting on CX3CR1, has been shown to suppress excessive microglia activation. We found that disruption in FKN/ CX3CR1 signaling in young adult rodents decreased survival and proliferation of neural progenitor cells through IL-1β. Aged rats were found to have decreased levels of hippocampal FKN protein; moreover, interruption of CX3CR1 function in these animals did not affect neurogenesis. The age-related loss of FKN could be restored by exogenous FKN reversing the age-related decrease in hippocampal neurogenesis. There were no measureable changes in young animals by the addition of exogenous FKN. The results suggest that FKN/ CX3CR1 signaling has a regulatory role in modulating hippocampal neurogenesis via mechanisms that involve indirect modification of the niche environment. As elevated neuroinflammation is associated with many age-related neurodegenerative diseases, enhancing FKN/ CX3CR1 interactions could provide an alternative therapeutic approach to slow age-related neurodegeneration.

Demonstrating improved confinement of energetic ions is one of the key goals of the Wendelstein 7-X (W7-X) stellarator. In the past campaigns, measuring confined fast ions has proven to be challenging. Future deuterium campaigns would open up the option of using fusion-produced neutrons to indirectly observe confined fast ions. There are two neutron populations: 2.45 MeV neutrons from thermonuclear and beam-target fusion, and 14.1 MeV neutrons from DT reactions between tritium fusion products and bulk deuterium. The 14.1 MeV neutron signal can be measured using a scintillating fiber neutron detector, whereas the overall neutron rate is monitored by common radiation safety detectors, for instance fission chambers. The fusion rates are dependent on the slowing-down distribution of the deuterium and tritium ions, which in turn depend on the magnetic configuration via fast ion orbits. In this work, we investigate the effect of magnetic configuration on neutron production rates in W7-X. The neutral beam injection, beam and triton slowing-down distributions, and the fusion reactivity are simulated with the ASCOT suite of codes. The results indicate that the magnetic configuration has only a small effect on the production of 2.45 MeV neutrons from DD fusion and, particularly, on the 14.1 MeV neutron production rates. Despite triton losses of up to 50 %, the amount of 14.1 MeV neutrons produced might be sufficient for a time-resolved detection using a scintillating fiber detector, although only in high-performance discharges.

The hypervelocity impact facilities of the University of Kent are described. They comprise a 2 MV Van de Graaff accelerator for the electrostatic acceleration of dust particles (mass and velocities ) and a two-stage light gas gun firing millimetre-sized particles at . Results for impact ionization studies using iron dust accelerated in the Van de Graaff and hitting a variety of metal targets (gold, silver, indium, iron, rhodium and molybdenum) are presented. Over the range , the ionization yields are found to be similar to within a factor of 20 at low velocity and converge to within a factor of five at high velocity. The light gas gun is used to investigate the volumes of craters in metal targets for impacts of 1 mm diameter stainless steel spheres on aluminium at velocities in the range . For normal incidence the crater volume scales with the square of the impact velocity. For oblique impacts at a fixed velocity it is found that the crater volume scales with the cosine of the impact angle.

After completing the main construction phase of Wendelstein 7-X (W7-X) and successfully commissioning the device, first plasma operation started at the end of 2015. Integral commissioning of plasma start-up and operation using electron cyclotron resonance heating (ECRH) and an extensive set of plasma diagnostics have been completed, allowing initial physics studies during the first operational campaign. Both in helium and hydrogen, plasma breakdown was easily achieved. Gaining experience with plasma vessel conditioning, discharge lengths could be extended gradually. Eventually, discharges lasted up to 6 s, reaching an injected energy of 4 MJ, which is twice the limit originally agreed for the limiter configuration employed during the first operational campaign. At power levels of 4 MW central electron densities reached 3  ×  1019 m−3, central electron temperatures reached values of 7 keV and ion temperatures reached just above 2 keV. Important physics studies during this first operational phase include a first assessment of power balance and energy confinement, ECRH power deposition experiments, 2nd harmonic O-mode ECRH using multi-pass absorption, and current drive experiments using electron cyclotron current drive. As in many plasma discharges the electron temperature exceeds the ion temperature significantly, these plasmas are governed by core electron root confinement showing a strong positive electric field in the plasma centre.