No abstract

The univolved skin of 10 patients with dermatitis herpetiformis (DH) was examined for the presence of gluten antigens with the immunofluorescence technique using a rabbit anti-gliadin antiserum, human antibodies to wheat and to reticulin conjugated to fluorescein-isothiocyanate (FITC) and class-specific anti-human IgA immunoglobulin. In all patients, IgA deposits were found in the tips of the dermal papillae of the uninvolved skin. With the anti-wheat and anti-reticulin conjugates, as well as with the rabbit anti-gliadin antiserum, no specific immunofluorescence was observed in any of the skin specimens. Skin biopsy sections of three DH patients were treated with an acid solution (pH 3.2) in an effort to dissociate antigen-antibody complexes that might be present. After the elution procedure the sections showed undiminished IgA fluorescence, and retesting with the anti-wheat- and anti-reticulin antisera again gave negative results. The skin eluates, two of which contained IgA, had no antibodies to wheat or reticulin. These findings do not give support to the hypothesis that the antigens in the suspected immune complexes in the DH skin consist of gluten.

Streaming services offer access to huge amounts of movie and video collections, resulting in the need for intuitive interaction designs. Yet, most current interfaces are focused on targeted search, neglecting support for interactive data exploration and prioritizing speed over experience. We present the MovieWall, a new interface that complements such designs by enabling users to randomly browse large movie collections. A pilot study proved the feasibility of our approach. We confirmed this observation with a detailed evaluation of an improved design, which received overwhelmingly positive subjective feedback; 80% of the subjects enjoyed using the application and even more stated that they would use it again. The study also gave insight into concrete characteristics of the implementation, such as the benefit of a clustered visualization.