No abstract

3H‐SCH 51048 and 14C‐SCH 56592 have been synthesized. 3H‐SCH 51048 was prepared in two steps by acid catalyzed tritium exchange while 14C‐SCH 56592 was prepared in three steps from 14C‐formamidine acetate in an overall 21% radiochemical yield. © 1998 John Wiley & Sons, Ltd.

Alkylation of 4(5)‐nitroimidazole‐5(4)‐sulfonamide with benzyl bromide occurred on both ring nitrogens. The structures of the products could be assigned by comparison of the chemical shifts of the sulfonamide hydrogens in the nmr spectra with those of the isomeric methyl derivatives, which were prepared by differing routes. Uv and nmr spectral data are reported for a number of bromo‐, nitro‐, mercapto‐, sulfamyl‐ and amino‐ substituted imidazoles as well as for both of the isomeric methylated derivatives of the series.

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14C‐Felbamate, 2‐[ring‐U‐14C]phenyl‐1,3‐propanediol‐dicarbamate, (1), was synthesized. The carbon label was introduced into Felbamate using uniformly labelled diethyl 2‐phenylmalonate as the starting material. © 1997 John Wiley & Sons, Ltd.