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A 42-year-old woman presented to the Department of Dermatology & Venereology, Virgen de las Nieves Hospital, Granada, Spain, in May 2015 with a severe pruritic rash and hair loss in both axillary regions. Physical examination showed skin coloured papules and alopecia [ Figure 1A], which showed no fluorescence under a Wood's lamp. Dermoscopy revealed hair follicle-centred papules, Figure 1A-D: A 42-year-old woman with Fox-Fordyce disease with (A) skin coloured papules of 1-2 mm and moderate alopecia in the right axilla and (B) folliculocentric papules with a few traumatised terminal hairs and blackheads. Haematoxylin and eosin stains showed (C) inflammatory infiltrate of lymphocytes affecting the follicle at x10 magnification and (D) eccrine and apocrine sweat glands showing dilatation at x4 magnification.interesting medical image

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A 33-year-old Spanish male presented to the Department of Dermatology & Venereology at the Virgen de las Nieves Hospital, Granada, Spain, in February 2015 with pruritic skin lesions located over a tattoo on his right arm. The tattoo had been completed three months earlier without protective measures by the patient's friend at his home. At presentation, the patient was not suffering from any known illnesses. A physical examination showed several pearled papules of 0.3-0.5 cm located over the tattoo [ Figure 1A]. The papules were umbilicated and occurred over the lines of the tattoo [ Figure 1B]. Biochemical tests and a haemogram were normal. Serology for hepatitis B and C, human immunodeficiency virus (HIV) and syphilis was negative. The patient was diagnosed with molluscum contagiosum (MC) and treated with curettage, with a subsequent healing time of three weeks.

Actinic cheilitis (AC) is a chronic inflammation of the lip considered an oral, potentially malignant disorder associated with an increased risk of lip squamous cell carcinoma (SCC) development. Controversies surrounding current therapeutic modalities of AC are under debate, and the implications of laser treatment have not been specifically investigated through a systematic review design. The present study aims to evaluate the degree of evidence of laser for the treatment of AC in terms of efficacy and safety. We searched for primary-level studies published before January 2022 through MEDLINE/PubMed, Embase, Web of Science, Scopus and CENTRAL, with no limitation in publication language or date. We evaluated the methodological quality and risk of bias of the studies included using the updated Cochrane Collaboration’s tool for assessing risk of bias (RoB-2). Twenty studies (512 patients) met our eligibility criteria. Laser therapy showed a complete clearance of AC in 92.5% patients, with a maximum recurrence rate of 21.43%, and a very low frequency of malignant transformation to SCC (detected in only 3/20 studies analyzed). In addition, cosmetic outcomes and patient satisfaction were described as excellent. In conclusion, our findings indicate that laser therapy is a high efficacy approach to AC.