A distinct characteristic of reservoir fluids in different Brazilian pre-salt fields is the high Gas-Oil- Ratio (GOR) and high content of CO2 in the associated gas. In particular, the presence of CO2 in significant amounts is known to have a strong influence on the thermophysical properties and phase equilibria of the oil mixtures. Due to the strategy of re-injection of CO2-rich streams for EOR purposes, these aspects can be even more pronounced in the production fluids in future scenarios. In the present work, a parametric study is performed to investigate the influence of both CO2 molar content and GOR, in a controlled manner, on the simulations of a pre-salt field configuration for various operating conditions. PVT look-up tables were used with a commercial multiphase flow simulator. First, the thermodynamic modelling of a 20% molar CO2 pre-salt oil was performed, along with well characterized CO2-live oil mixtures taken from the literature, in order to generate PVT look-up tables. They were used to successfully reproduce field data and assess the validity of multiphase flow simulation results from a commercial software. For the CO2-rich live oil mixtures from the literature, a parametric study was performed in which the CO2 molar content ranged from 20% to 50% with 300-600 Sm3/Sm3 of GOR. Simulation results of temperature, total pressure drop, gas volume fraction and gas- liquid density ratio are presented and compared.