Agents targeting nuclear kinases appear to be effective in SCLC lines. Confirmation of SCLC line findings in xenografts is needed. The drug and compound response, gene expression, and microRNA expression data are publicly available at http://sclccelllines.cancer.gov.

The most widespread eolian deposits of the Victoria Land dry valleys, Antarctica, are pebble ripples which appear to b" of larger size than those r,eported from other continents. The crests of the ripples are composed of grains with a greater diameter than the grains of the flanks. The mean ripple index of 23 is higher than that of large ripples reported from outside Antarctica, and there does not seem to be a simple relationship between index and grain size. The high winds and high·density cold air of Antarctica appear capable of moving the largest pebbles which have a diameter of 19 mm.Sand forming transverse and whaleback dunes in the Victoria Valley is derived from the outwash from the Victoria Lower Glacier. The sand in the dunes is interbedded with snow, and moisture from this allows the dunes to be permafrosted except for a thin surface layer of dry mobile sand. The mobile sands of the transverse dunes are seasonally reversing. The sands of the dunes are well sorted and there is no selectiv5 deposition of a particular grain size in any area of the dunes. A characteristically granule-size lag deposit occurs on some interdune areas, and on the wha1ehack dunes, where it controls the size of the ripples. The granules may be in the critical size range for stabilising ripples which move only during infrequent very high velocity winds.

No abstract

In identifying controls on rock slope form a distinction is made between: (1) rock slopes with joints which dip steeply out of a cliff and hence are subject to mass failure of the rock mass above a critical joint; and (2) rock slopes with inclinations which are either in equilibrium with the mass strength of their rocks, or have profiles which will develop towards strength equilibrium as cross joints open. In the first class of slope, stability results not just from the basic frictional resistance of the rock but also from the frictional roughness along the critical joint and from the normal stress acting across that joint. Stability may be reduced by weathering and loss of strength of the joint wall rock. As a result of normal stress variations with depth, induced by overburdens, high cliffs which are not undercut have a concave profile. The second group of slopes includes those with inclinations controlled at the scale of individual joint blocks, buttressed slopes and those on unjointed rock masses. Buttressed and unjointed rock masses develop towards a condition of mass strength equilibrium as cross joints open. Strength equilibrium slopes may be recognized by application of a rock mass strength classification proposed for geomorphic purposes. Eleven propositions are formulated which identify controls on rock slope development and some consequences of these controls.KEY WORDS Joint friction angle Strength equilibrium Rock mass strength Rock slope profile Normal stress

This study examined the relationship between hostility and depression in depressed and nondepressed subjects as well as the reliability and validity of several measures of anger, hostility and depression. Sixty-nine subjects were evaluated for depression using the Hamilton Rating Scale for Depression (HRSD; Hamilton, 1960). These subjects were then administered the Beck Depression Inventory (BDI; Beck, Ward, Mendelson, Mock, & Ergaugh, 1961), Buss-Durkee Hostility Inventory (BDHI; Buss & Durkee, 1957), Hostility and Direction of Hostility Questionnaire (HDHQ; Foulds, Caine, & Creasy, 1960) and the State-Trait Anger Scale (STAS; Spielberger, Jacobs, Russell, & Crane, 1983). Results showed the BDI, STAS-TRAIT, HDHQ, and BDHI to have good temporal stability. Support was found for the convergent validity of all measures of depression, hostility, and anger. Limited discriminant validity was found between measures of anger and hostility and measures of depression. This latter finding was interpreted as lending support for the relationship between hostility and depression rather than as an indication of limited construct validity for the measures. Intercorrelations among hostility, anger, and depression scales offer some support for the hypothesis that depression is linked most strongly with attitudinal versus motoric forms of hostility. However, normative data suggests that both forms of hostility increase with severity of depression. Clinical implications and directions for further research are discussed.